Studies on viridenomycin, a novel 24-membered macrocyclic polyene lactam antibiotic.

Sceliphrolactam, a Polyene Macrocyclic Lactam from a Wasp-Associated Streptomyces sp.

A previously unreported 26-membered polyene macrocyclic lactam, sceliphrolactam, was isolated from an actinomycete, Streptomyces sp., associated with the mud dauber, Sceliphron caementarium. Sceliphrolactam's structure was determined by 1D- and 2D-NMR, MS, UV, and IR spectral analysis. Sceliphrolactam displays antifungal activity against amphotericin B-resistant Candida albicans (MIC = 4 μg/mL,...

Cremimycin, a novel 19-membered macrocyclic lactam antibiotic, from Streptomyces sp.

A novel 19-membered macrocyclic lactam antibiotic, cremimycin, was isolated from the culture broth of an actinomycete strain. The producing organism, designated MJ635-86F5, was identified as a member of Streptomyces. Cremimycin was isolated from the mycelial cake by extraction with CHCl3-MeOH and precipitation with hexane-MeOH. The structure of cremimycin was determined by spectroscopic study. ...

GT32-B new 20-membered macrocyclic lactam antibiotic.

Studies towards the synthesis of the northern polyene of viridenomycin and synthesis of Z-double bond analogues.

Viridenomycin is a structurally challenging, potentially biologically valuable molecule which has yet to succumb to total synthesis. Its instability, perhaps particularly associated with the northern polyene may contribute to the difficulties of piecing this molecule together. The synthesis of northern polyene models, including potentially stabilised analogues incorporating benzene rings as Z-a...

Isolation, physico-chemical properties and structure elucidation studies on HA-2-91 , a new tetraene polyene antifungal antibiotic produced by Streptomyces arenae var ukrainiana

Polyene antibiotics a re characterized to have 26 to 38 membered macrocyclic lactone ring contain ing 3 to 8 conjugated double bonds t and most of them possess remarkable antifungal activity. The polyenes are grouped according to the number of double bonds present in the molecule and it has been rep.orted that the an tifungal activity increases s ignificantl y with the presence of more conjugat...